Monday, 18th February 40th Annual Lorne Genome Conference 2019
Breakfast Workshop: Long Read Sequencing
7:30AM - 8:40AM
Monday, 18th February
Horizons Room
Chair: Joseph Powell
Sponsored by:
Micro Break
8:40AM - 8:50AM
Monday, 18th February
Auditorium Foyer
Session 2: Big Data Science
8:50AM - 10:15AM
Monday, 18th February
Auditorium
Chairs: Juliet French & Greg Neely
Sponsored by:
- A year of human spaceflight: (epi)genome changes, RNA responses, and mtDNA spikes - Christopher Mason
- GWAS, metabolites and Mendelian disorders: identifying the genetic drivers of MacTel, a rare, but complex eye disorder - Melanie Bahlo
- Early origin of developmental enhancers in animals - Emily SW Wong
Morning Tea
10:15AM - 11:00AM
Monday, 18th February
Exhibition Hall
Session 3: Gene Regulation
11:00AM - 12:42PM
Monday, 18th February
Auditorium
Chairs: Ewa Michalak & Austen Ganley
Sponsored by:
- De novo DNA methylation punctuated with relaxed 3D chromosome architecture including transposon-rich heterochromatin opening during gonocyte - Haruhiko Siomi
- Not made available - Jason Moffat
- Human sex reversal is caused by duplication or deletion of core enhancers upstream of SOX9 - Brittany Croft
- Setdb1 regulates JAK-STAT signalling by repressing Suppressor of Cytokine Signalling 3 (Socs3) expression - Andrew Jarratt
Lunch
12:45PM - 1:15PM
Monday, 18th February
Exhibition Hall
Afternoon Workshop: A career = You + Science + Audience
1:15PM - 2:45PM
Monday, 18th February
Horizons Room
Chair: Traude Beilharz
Sponsored by:
Micro Break
2:45PM - 3:00PM
Monday, 18th February
Auditorium Foyer
Session 4A: Regulation of Gene Expression
3:00PM - 4:00PM
Monday, 18th February
Auditorium
Chairs: Ryan Lister & Megan Bywater
- RNA exploits an exposed regulatory site to inhibit the histone methyltransferase PRC2 - Chen Davidovich
- Rescue of Myc transcriptional activity in the heart unlocks its proliferative capacity - Megan J Bywater
- Coordinating genome expression with cell size and shape - Scott Berry
- Multi-dimensional analysis of the breast tumour microenvironment at single-cell resolution - Simon Junankar
Session 4B: Disease & Development
3:00PM - 4:00PM
Monday, 18th February
Horizons Room
Chairs: Kate Quinlan & Tamas Fischer
Sponsored by:
- Mapping promoter-enhancer interactions of neuromuscular disease genes - Joe Kin Tung Tam
- Cellular characterisation of brain malformation using single nuclei RNA-seq. - Sarah Stephenson
- Using CRISPR gene editing coupled to high-throughput functional assays to improve diagnosis of rare neuromuscular diseases. - Keryn G Woodman
- Chromosome structure at telomeres: resolution of G-quadruplexes by telomerase - Tracy M Bryan
Afternoon Tea
4:00PM - 4:30PM
Monday, 18th February
Exhibition Hall
Session 5: Noncoding RNA and RNA Regulation
4:30PM - 6:23PM
Monday, 18th February
Auditorium
Chairs: Alistair Forrest & Minna-Liisa Anko
Sponsored by:
- Requirements for multivalent Yb body assembly in piRNA-mediated transposon silencing in Drosophila - Mikiko Siomi
- Interaction of modified oligonucleotides with nuclear proteins, formation of novel nuclear structures and sequence-independent effects on RNA processing - Sue Fletcher
- Regulation of neural development genes through histone acetylation - Maria I Bergamasco
- Visualization and genome-wide mapping of i-Motif DNA structures - Mahdi Zeraati
- Long-read sequencing reveals the expression and splicing profiles of neuropsychiatric disease genes in human brain - Michael B Clark
- Pax5 organises the B cell genome in three-dimensions independent of transcription - Timothy M Johanson
- lncRNA expression and function in the human placenta - Tina Bianco-Miotto
- Order and disorder in the nucleus – how chromatin folding and misfolding impact T cell differentiation - Brendan Russ
Dinner Break
6:25PM - 8:30PM
Monday, 18th February
Poster Session 2
8:30PM - 10:30PM
Monday, 18th February
Exhibition Hall
- CDK9 function in erythroid enucleation - Krystle Lim
- Molecular Dissection of Box Jellyfish Venom Cytotoxicity Highlights an Effective Venom Antidote - Jamie B Littleboy
- Single-cell transcriptomic analysis of mouse neocortical development - Lipin Loo
- Investigating the role of ZBTB7A homodimerisation in foetal γ-globin repression - Lana C Ly
- The ZYG11 family - keeping cells in shape - Charlene M Magtoto
- Histone readers required for heart epicardium formation and differentiation - Sophia Mah
- SETDB2 mutations suppress pain perception in flies and mice, and cause congenital insensitivity to pain in humans - John Manion
- CREB-mediated transcription integrates diverse upstream pathways to modulate oncogenic signals - Theo Mantamadiotis
- Antiproliferative and autophagic effects caused by a new 2-quinoxalinyl-hydrazone in colorectal cancer cells - Sarah S Maranhao
- ELEVATED FOETAL GLOBIN CAUSED BY A NATURAL REGULATORY MUTATION WHICH CREATES A DE NOVO GATA1 SITE - Gabriella E Martyn
- Identification and functional characterization of evolutionarily conserved cancer testis antigens (CTAs) - Natasha Masand
- The devil inside: Preliminary dietary analysis reveals a broad depth of prey items in an island population of Tasmanian devils (Sarcophilus harrisii) - Elspeth McLennan
- A mechanistic insight into building the embryonic head - Riley McMahon
- The histone reader protein, PHF6, is a new tumour suppressor - Helen M McRae
- Investigating Antisense Oligonucleotide Therapeutics for Amyotrophic Lateral Sclerosis - Rita Mejzini
- Mammary stem cell hierarchy maintenance by GPSM2 and asymmetric cell division - Michal Milgrom Hoffman
- NT2/D1 cells model SOX9 function in the mammalian testis - Zhenhua Ming
- Epigenome-wide association studies (EWAS) of neurodevelopmental disorders using monozygotic twins - Namitha Mohandas
- ATZ-1 influences meiosis and maintains germline chromosomal stability in Caenorhabditis elegans - Luke W Molesworth
- Remodelling the interior: How the nucleus is reconfigured to regulate CD8+ T cell differentiation. - Alison Morey
- Evolutionary sequence conservation reveals the majority of human long non-coding RNAs are likely non-functional - Walter Muskovic
- NEAT1 long noncoding RNA isoform-switching using antisense oligonucleotides regulates paraspeckle formation in high-risk neuroblastoma cells - Alina Naveed
- How did the red blood cell lose its nucleus? - Lucas M Newton
- Systems Analysis of Adult Tissue Fibroblasts Transcriptomic Identity - Hieu T Nim
- Whole genome CRISPR/Cas9 screens identify regulators of the DNA replication stress response - Aisling O'Connor
- Zebrafish preserve germline epigenetic memory globally but demethylate and amplify sex-linked rDNA during feminisation - Oscar Ortega-Recalde
- Systematic functional validation of Parkinson's disease GWAS identifies MCMBP as a potential therapeutic target - Lisa Oyston
- The novel roles of histone demethylase KDM4A - Konstantin Panov
- First differential transcriptome analysis between juvenile and adult echidna gonads - Tahlia Perry
- Distinct microglial phenotypes in Alzheimer’s disease are controlled by amyloid plaque phagocytosis - Enrico Petretto
- Antisense Oligomer-induced Exon Skipping to Restore Dysferlin Function in LGMD2B Patients - Bal Hari Poudel
- Eosinophils express secreted factors to directly drive activation of beige adipose tissue - Kate GR Quinlan
- Novel mechanism for stem-cell specific miRNA regulation in development and disease - Madara Ratnadiwakara
- A synthetic reference unit for measuring quantitative features of genome biology - Andre Reis
- Novel DNA demethylation pathway components revealed through reverse genetic screening in vivo - Samuel Ross
- Functional analysis of RING and NHL domains of NHL-2 in C.elegans miRNA pathway. - Nasim Saadati
- Unveiling the Mixl1 gene regulatory network underpinning mouse endoderm formation using in silico transcription factor binding prediction - Nazmus Salehin
- Accelerated Deep learning genomics analysis on GPUs - Werner Scholz
- Depletion of Cohesin Factor Rad21 Alters Genome Organisation around Key Transcription Factors During Zygotic Genome Activation - William Schierding
- How does a transcription factor find its targets? - Manan Shah
- THOC2 variation implicates nuclear mRNA export pathways in neurodevelopmental disorders - Raman Sharma
- Translation complex profile sequencing in yeast and human cells - Nikolay Shirokikh
- Using the Missense Tolerance Ratio to prioritise disease-causing mutations and to identify novel functional features in gene sequences and protein structures - Michael Silk
- Scribble on the edge: localisation of a tumour suppressor - Rebecca Stephens
- Functional analysis of cardiac-specific regulatory elements involved in heart development and disease - Julian Stolper
- Phenotypic Heterogeneity in Blood Disorders: The Role of XmnI-Gγ in γ-Globin Expression - Elizabeth S Stout
- Using fluorescence polarisation approach to optimise DNA pulldown assay - Yu Bo Yang Sun
- Exonic sequencing implicates PRRT2, SLC2A1, SLC4A4 and CSNK1D gene variants in hemiplegic migraine - Heidi G Sutherland
- Normalase – A Novel Library Normalization Tool for High-Throughput NGS - Andrew Szentirmay
- Smchd1’s role in directing long-range chromatin interactions - Andres Tapia del Fierro
- The Use of Audio for DNA Sequence Analyses: The Sound of Genes - Mark D Temple
- Population structure and genetic diversity of Cryptosporidium hominis by Whole Genome Sequencing - Swapnil Tichkule
- Genome-wide CRISPR screening reveals loss of STAGA complex activity mediates resistance to CDK7 inhibition - Izabela Todorovski
- Using genome editing to introduce naturally occurring deletional mutations associated with elevated foetal haemoglobin as an approach for treating sickle cell disease and β-Thalassemia - Sarah Topfer
- Investigating the key mechanisms of alternative polyadenylation - Rachael E Turner
- Data-driven approach to screen ncRNA in prokaryotes - Sonika Tyagi
- USP48 directly antagonises BRCA1-driven histone ubiquitination to regulate chromatin remodelling in response to DNA damage. - Michael Uckelmann
- Characterising changes in ribosomal DNA chromatin during malignant transformation - Thejaani Udumanne
- Elucidating the Role of PRC1 Complex in CD8+T Cell Differentiation - Vibha A.V. Udupa
- Predicting individual variation in chromatin architecture from RNA-Seq data - Lucas van Duin
- Hippo pathway effectors, YAP and TAZ, in craniofacial cartilage development - Hannah K Vanyai
- Developing guidelines for researchers partnering with Aboriginal and/or Torres Strait Islander people and communities to undertake genomic research. - Miranda E Vidgen
- Krüppel-like factor 3 (KLF3) regulates adipose tissue browning via eosinophils - Emily J Vohralik
- The H3.3 K27M Mutation Found in Paediatric Gliomas Alters H3K27me3 at Genomic Repeats - Hsiao Voon
- Diagnostic yield from WES, WGS and RNA testing among 213 neuromuscular families: known versus novel disease genes, coding versus non-coding variants. - Leigh B Waddell
- Changes in placental DNA methylation across early human pregnancy - Qianhui Wan
- Smchd1 is a maternal effect gene that plays a significant role in genomic imprinting during early embryonic development - C I Wanigasuriya
- Shining light on the MYST lysine acetyltransferase TIP60 (KAT5) - Johannes Wichmann
- Factors beyond binding site complementarity contribute to miRNA-mediated gene silencing - Gigi Wong
- Chromatin modifiers SET-25 and SET-32 establish a transgenerational silencing signal in Caenorhabditis elegans - Rachel M Woodhouse
- Unveil a distinct leukemia stem cell signature using integrative transcriptomics - Feng Yan
- Identification of a novel partner of KLF3 that plays an important role in KLF3 genome localisation - Lu Yang
- Histone acetyltransferase HBO1 (KAT7) regulates haematopoietic stem cell quiescence, self-renewal and lineage differentiation - Yuqing Yang
- Surprising roles for the ssDNA binding protein Psi in Drosophila neural stem cells: more than MYC transcription? - Olga Zaytseva
- Roles of RNA and DNA binding capacity of NONO in neuroblastoma - Song Zhang
- Atrial selectivity is driven by a complex Nuclear Receptor (cNRE) - Luana L Nunes Santos
- DNA Nanoballs and Single-Tube LFR: Affordable "Perfect" Genome Sequencing - Radoje Drmanac